Hasinika Gamage

Event Date: 
Tuesday, July 25, 2017 - 18:00 - 18:15
Macquarie University

Fibre products derived from sugarcane, wheat dextrin and psyllium husk have different effects on the gut microbiota


Diets low in complex polysaccharides have been shown to perturb the gut microbiota-host relationship, and thus impact host health. As evidence supporting this hypothesis continues to grow, therapeutic modulation of the gut microbiota through supplementation of complex polysaccharides for preventing or treating diseases has gained significant scientific and commercial interest. A number of supplements in the form of dietary fibre or prebiotics are marketed commercially for this purpose. However, only limited work has been conducted to scientifically evaluate the ability of these products to alter the gut microbiota and improve host health.  In this work, we investigated the impact of three commercially available dietary fibre products on the gut microbiota and metabolite production. We used an in vitro adult digestive and gut microbiota model system and high fat diet fed mice to examine the effect of dietary fibre supplementation on the gut microbiota, metabolites and host physiology.
Our results demonstrated significant shifts in the overall gut microbiota community structure upon addition of each product. The abundance of various bacterial taxa associated with fibre digestion and anti-inflammatory capabilities increased with fibre additions. However, the specific nature of the alterations was product-dependent. Fibre supplementation in mice ameliorated high fat diet-induced changes in the abundance of specific gut bacteria and host liver proteome, whilst no significant changes in the glucose clearance or body weight were observed.