Neospora caninum

JAMS celebrated July at the Australian Museum with a diverse series of talks and food and drinks, kindly supported by ASM.

Rita Rapa (UTS) started us off describing the integron/gene cassette system in the Vibrio genus. These gene cassettes add to the adaptive potential of Vibrio and are likely to be an important driver in the evolution of Vibrio in their respective niches. Through whole cell proteomic analysis, deletions in the gene cassette array exhibit altered surface associated structures. Her future work will focus on how these deletions impact Vibrio physiology.
Event Date: 
Wednesday, July 27, 2011 - 18:15 - 18:30
University of Sydney

Neosporosis: the nemesis of Australian fauna?


Neosporosis caused by an apicomplexan parasite Neospora caninum is a major protozoal reproductive disease in cattle and a recognised neurological disease in dogs. Currently, the majority of research on neosporosis has focused on cattle because the cattle industry identified the disease as a significant economic burden worldwide. However, virtually all vertebrates are assumed to be susceptible to neosporosis, with the degree of pathology varying between host species. Since no information exists on neosporosis in Australian native small marsupials, our aim was to provide evidence using experimentally infected animals. Our trial used Sminthopsis crassicaudata, the fat-tailed dunnart, a carnivorous marsupial widely distributed throughout the arid and semi-arid zones of Australia and one of only a few marsupial species bred in laboratory. The fat-tailed dunnart inhabits the same geographical areas as the dingo, feral fox and rangeland cattle, and, as its name suggests, its fat is stored in the tail, from a few millimetres from the base and almost to the tip. In contrast to existing models that develop relatively few N. caninum tissue cysts, dunnarts offer a new animal model in which active neosporosis is dominated by tissue cyst production. The results provide evidence for a sylvatic life cycle of N. caninum in Australia between marsupials and wild dogs. It establishes the foundation for an investigation of the impact and costs of neosporosis to wildlife.

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