Despite miserable weather conditions, a sizeable crowd gathered at the Australian museum for the first JAMS meeting of 2012.
Dean Procter from the University of Sydney kicked off with our first virology talk of the year at JAMS. He introduced us to the live virus vaccine used to eradicate smallpox, Vaccinia virus. It encodes three BTB-Kelch protein orthologues in the Ubiquitin-Proteasome System, where host cell proteins are selectively degraded. This mechanism can prevent the establishment of an antiviral immune response enabling it to become a viral production factory enhancing viral spread. The identification of the substrates may indicate new mechanisms by which these viruses overcome cellular defenses to cause infection.